{"id":22938,"date":"2024-09-17T00:59:21","date_gmt":"2024-09-16T16:59:21","guid":{"rendered":"https:\/\/thei.hhe-service.com\/?p=22938"},"modified":"2025-04-14T17:33:47","modified_gmt":"2025-04-14T09:33:47","slug":"investigation-of-novel-antifungal-agents","status":"publish","type":"post","link":"https:\/\/thei.edu.hk\/sc\/investigation-of-novel-antifungal-agents\/","title":{"rendered":"\u65b0\u578b\u6297\u771f\u83cc\u5242\u7684\u8868\u5f81"},"content":{"rendered":"
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(\u53ea\u63d0\u4f9b\u82f1\u6587\u7248\u672c)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Paul Tsang<\/a>, School of General Education and Languages<\/strong><\/p>

\u00a0<\/h6>

\"\"<\/p>

Dr Tsang’s Research Team<\/strong><\/p>

\u00a0<\/p>

Candidiasis is an infection caused by the fungus\u00a0Candida albicans\u00a0<\/em>and it attacks patients with impaired immunity.\u00a0\u00a0<\/em>Since the disease has a high death rate, it has been ranked fourth amongst hospital-acquired infections.\u00a0 Conventional antifungal agents are available, but they either have severe side effects or poor absorption.\u00a0 In addition, overuse of antifungal agents often leads to emergence of antimicrobial resistance that adversely affects the management of fungal infections in clinical settings.\u00a0 Thus, there is a dire need to search for novel antifungal agents.<\/p>

Dr Paul Tsang and his research team have been examining substances with novel antifungal activities via various biochemical tests.\u00a0 They identified that purpurin, a natural red dye from madder root (Rubia tinctorum<\/em>\u00a0L.), was able to inhibit fungal growth.\u00a0 Purpurin is generally used in food coloring and cotton printing; however, it exhibits inhibitory effects on six species of\u00a0Candida<\/em>\u00a0fungi at concentrations as low as 1.28 \u03bcg\/mL (Kang, Fong, & Tsang, 2010).<\/p>

The team reported encouraging results of purpurin to suppress several disease-causing factors (virulence traits) of\u00a0Candida<\/em>\u00a0fungi, namely filamentation and biofilm formation.\u00a0 Filamentation refers to the transition of physical forms of some\u00a0Candida<\/em>\u00a0fungi and is essential for biofilm development to infect humans.<\/p>

The discovery of purpurin expands the repertoire of conventional antifungal interventions.\u00a0 One aspect of the potential uses of purpurin could be a combined application with conventional antifungal agents in cocktail therapy against pathogenic\u00a0Candida<\/em>\u00a0fungi with a reduced likelihood of resistance.\u00a0 The findings of purpurin were published in four peer-reviewed international journals and the article by Tsang, Bandara, and Fong (2012) in\u00a0PLOS ONE<\/em>\u00a0was awarded \u201cResearch Output Prize\u201d by the University of Hong Kong.<\/p>

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(\u53ea\u63d0\u4f9b\u82f1\u6587\u7248\u672c) Dr Paul Tsang, School of General Education and Languages Dr Tsang’s Research Team Candidiasis is an infection caused by the fungus\u00a0Candida albicans\u00a0and it attacks patients with impaired immunity.\u00a0\u00a0Since the disease has a high death rate, it has been ranked … <\/p>","protected":false},"author":104,"featured_media":45024,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[75],"tags":[24],"ppma_author":[194,196,197],"class_list":["post-22938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-impact-research","tag-alumni"],"yoast_head":"\nInvestigation of Novel Antifungal Agents - Technological and Higher Education Institute of Hong Kong<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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