Viral infections pose significant health challenges globally, with limited treatment options for many pathogens. In this study, we screened over 500 extracts from medicinal plants in the Lingnan region, leading to the identification of Maesa perlarius as a notable source of procyanidins with antiviral effects. The methanol extract of this plant demonstrated a significant inhibitory effect against viral pseudotyped particles, with an IC₅₀ of 0.52 µg/mL. Further bioassay-guided fractionation isolated several active procyanidins, exhibiting IC₅₀ values ranging from 0.83 to 36.0 µM. Molecular docking studies suggest that these compounds may interact with viral glycoproteins, highlighting their potential mechanism of action. The findings suggest avenues for the commercialization of procyanidins as antiviral agents, providing a basis for developing new therapeutics and dietary supplements aimed at enhancing public health.

Acknowledgement

The presenter is grateful to  Prof. Zhang Hong-Jie’s research team (Hong Kong Baptist University, Kowloon, Hong Kong, China), Prof. Rong Lijun’s research team (University of Illinois Chicago, Chicago, IL, US), and  Robert Davey (Boston University, Boston, MA, USA) for their contributions to the research.