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  2. Dr CHAN Shun Wan

TEACHING AREAS

  • Nutritional Science
  • Healthcare Management
  • Physiology and Pharmacology
  • Epidemiology
  • Functional Food
  • Medical Microbiology
  • Biochemical & DNA Technologies
  • Biostatistics

QUALIFICAIONS

  • B.Sc. (Hons.) in Animal and Plant Biotechnology, The University of Hong Kong, 1996
  • Ph.D. in Pharmacology, The Chinese University of Hong Kong, 2000
  • M.Ed. in Teaching in Professional, Vocational and Higher Education, The Hong Kong Polytechnic University, 2004
  • Pg. Dip. in Epidemiology and Biostatistics, The Chinese University of Hong Kong, 2004
  • Cert. in Microbiology Testing, The University of Hong Kong School of Professional and Continuing Education, 2014

EMPLOYMENT

2019 - Present Associate Professor & Programme Leader of 1) BSc (Hons.) in Nutrition and Healthcare Management; and 2) BSc (Hons.) in Testing and Certification, Technological and Higher Education Institute of Hong Kong, Tsing Yi, Hong Kong
2016 - 2019 Associate Professor & Programme Leader of 1) BSc (Hons.) in Food Science and Safety; and 2) BSc (Hons.) in Testing and Certification, Technological and Higher Education Institute of Hong Kong
2014 - 2017 Visiting Assistant Professor, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University.
2014 - 2016 Assistant Professor & Programme Leader for BSc (Hons.) in Food Science and Safety, Technological and Higher Education Institute of Hong Kong, Tsing Yi, Hong Kong
2014 - 2017 Associate Director, State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, China.
2012 - 2017 Assistant Director, Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University.
2012 - 2014 Assistant Director, State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, China.
2000 - 2014 Demonstrator, Instructor to Teaching Fellow, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University.

PROFESSIONAL SOCIETIES AND AFFILIATION

2014 - Present 香港Q唛標誌委員會技術專家，香港
2012 - 2015 香港食品科技協會內部副主席
2010 - 2012 香港食品科技協會會員

AWARDS

Best Poster Prize, Ultra-performance liquid chromatography-mass spectrometry, a tool to estimate the treatment effect of the water extract of Polygonum cuspidatum (Hu Zhang) in diet-induced hypercholesterolemic rats. 3rd International Conference and Exhibition on  Advances in Chromatography & HPLC Techniques, July 13-14, 2017 Berlin, Germany  

RESEARCH GRANT

  • Competitive Research Funding Schemes for the Local Self-Financing Degree Sector (Research Grants Council, HKSAR) (2017-2020): The synergistic effect of using pioglitazone in combination with piceatannol in treating nonalcoholic fatty liver disease in rats. HK$ 999,910 (an external competitive grant) (Principle Investigator)
  • Competitive Research Funding Schemes for the Local Self-Financing Degree Sector (Research Grants Council, HKSAR) (2018-2021): A mechanistic study on the combination uses of doxorubicin with Salvia Miltiorriza Bunge (Danshen) in treating drug-resistant hepatocellular carcinoma in vitro and in vivo. HK$ 809,010 (an external competitive grant) (Principle Investigator)
  • THEi seed grant (Technological and Higher Education Institute of Hong Kong) (2015-2016): Investigation on the role of esculetin on protecting neuronal cell death induced by 6-hydroxydopamine. HK$ 100,000 (an internal grant) (Principle Investigator)
  • THEi seed grant (Technological and Higher Education Institute of Hong Kong) (2017-2018): Design and synthesis of luminescent metal complexes as chemosensors for environmental and food safety monitoring. HK$ 90,000 (an internal grant) (Co-Investigator)
  • Environmental Education and Community Action, HKSAR (2017-2019) ECF The iFood Campaign. HK$ 374,952 (an external competitive grant) (Principle Investigator)
  • Health Care and Promotion Scheme (HCPS), Health and Medical Research Fund (HMRF), HKSAR, Food and Health Bureau (2018-2019) Promotion of Dietary and Cognitive Health in Dementia Prevention to Elderly Community – A Pilot Project. HK$ 99,570 (an external competitive grant) (Principle Investigator)
  • Environmental Education and Community Action, HKSAR (2017-2019) ECF Rational Use of Chinese Medicinal (CM) Residues, Treat the Chinese Medicinal Pulp Properly---Save Money, Healthy and Environmentally Friendly. HK$444,701 (an external competitive grant) (Co-Investigator)
  • General Research Fund - University Grants Committee, HKSAR (2019-2021) Mass spectrometry based metabolomics studies on the effects of using piceatannol in treating non-alcoholic fatty liver disease in rats and the role of gut microbiota modulation. HK$505,289 (an external competitive grant) (Co-Investigator)
  • Professional Services Advancement Support Scheme (PASS), The Commerce and Economic Development Bureau, HKSAR (2019-2021) Establish an Exchange Platform for Chinese Medicine Pharmaceutical Professionals in Guangdong-Hong Kong-Macau Greater Bay Area. HK$1,058,000 (an external competitive grant) (Co-Investigator)
  • FHB’s Health and Medical Research Fund subsidises COVID-19 research, HKSAR (2020-2022) Utilization of CRISPR/cas9-modified Lactobacillus casei as an oral vaccine for treating and preventing COVID-19 infection. HK$2,972,960 (an external competitive grant) (Co-Investigator)
  • Chinese Medicine Development Fund, HKSAR (2021-2022) One School, One TCM garden. HK$689,200 (an external competitive grant) (Co-Investigator)
  • Donation and Research Matching Grant Scheme (RGC), HKSAR (2021-2022) Develop probiotic based health products for elderly. HK$400,000 (a donation and matching grant) (Principle Investigator)
  • Competitive Research Funding Schemes for the Local Self-Financing Degree Sector (Research Grants Council, HKSAR) (2022-2024): A mechanistic study on the combined use of esculetin and probiotics in preventing Parkinson’s disease in mice. HK$1,248,950 (an external competitive grant) (Principle Investigator)

RESEARCH EXPERIENCE

Member of Editorial Boards

 

RESEARCH INTERESTS

  • Pharmacology
  • Cardiovascular physiology
  • Chinese medicine
  • Functional food
  • Food safety
  • Toxicology
  • Microbiology
  • Probiotics

SELECTED PUBLICATION

 

  1. Li SL, Chan SW, Li P, Lin G, Zhou GH, Ren YJ, Chiu FCK. (1999) Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria. Journal of Chromatography A. 859:183-192.
  2. Li SL, Li P, Lin G, Chan SW, Ho YP. (2000) Simultaneous determination of seven major isosteroidal alkaloids in bulbs of Fritillaria by gas chromatography. Journal of Chromatography A. 873:221-228.
  3. Chan SW, Li SL, Lin G, Li P. (2000) Pharmacokinetic study and determination of imperialine, the major bioactive component in antitussive Fritillaria cirrhosa, in rat by high-performance liquid chromatography coupled with evaporative light scattering detector. Analytical Biochemistry. 285:172-175.
  4. Li SL, Lin G, Chan SW, Li P. (2001) Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high performance liquid chromatography coupled with evaporative light scattering detector. Journal of Chromatography A. 909:207-214.
  5. Sum TSW, Chan SW, Rudd JA, Yeung JHK. (2001) Actions of glucocorticoids to antagonise cisplatin-induced acute and delayed emesis in ferret. European Journal of Pharmacology. 417:231-237.
  6. Lin G, Li P Li SL, Chan SW. (2001) Chromatographic analysis of Fritillaria isosteroidal alkaloids, the active principles of the most commonly used antitussive traditional Chinese medicine Beimu. Journal of Chromatography A. 935:321-338.
  7. Kwok CY, Chan SW, Yu PHF. (2004) Effects of Shan Zha on the cardiovascular system. Hong Kong Food Science and Technology Association 7th Anniversary Commemorative Publication. 48-51.
  8. Chan SW*. (2004) Review of scientific research on edible bird’s nest. Hong Kong Food Science and Technology Association 7th Anniversary Commemorative Publication. 39-43.
  9. Li WY, Chan SW, Yu PHF, Guo DJ, Zhong XQ. (2005) Study on the Antioxidant and Anticancer Effects of Water Extracts of Five Selected Chinese Medicinal Herbs. Hong Kong Food Science and Technology Association 8th Anniversary Commemorative Publication. 34-39.
  10. Wong MF, Chan SW, Guo DJ, Zhong XQ, Yu PHF. (2005) Vasorelaxation effect of emodin, an active ingredient from Radix et Rhizoma Rhei (Da Huang). Hong Kong Food Science and Technology Association 8th Anniversary Commemorative Publication. 49-52.
  11. Ng KM, Chan SW*. (2005) Tea: the origin and medicinal use. Hong Kong Food Science and Technology Association 8th Anniversary Commemorative Publication. 46-48.
  12. Lee YK, Kwok CY, Chan SW, Yu PHF, Guo DJ, Zhong XQ. (2005) Review of Scientific Researches on Anticancer Effects of Lycium barbarum (Gou Qi Zi). Hong Kong Food Science and Technology Association 8th Anniversary Commemorative Publication. 53-56.
  13. Li WY, Guo DJ, Chung MK, Leung TY, Chan SW, Yu PHF, (2006) Effects of emodin, an active ingredient from Radix et Rhizoma Rhei (Da Huang), on the proliferation inhibition and apoptosis induction in A549 and MCF-7 cells. Hong Kong Food Science and Technology Association 9th Anniversary Commemorative Publication. 44-49.
  14. Wong MF, Chan SW, Guo DJ, Yu PHF. (2006) A scientific review on the functions of a Traditional Chinese Medicine: Evodia rutaecarpa, Wu Zhu Yu. Hong Kong Food Science and Technology Association 9th Anniversary Commemorative Publication. 50-53.
  15. 閆莉萍, 陳舜宏, 陳偉民, 陳士林, 馬小軍, 徐宏喜. (2006) 葛根素對膳食誘導的高膽固醇血症大鼠的血脂調節作用. 中國臨床藥理學與治療學. 11: 574-577.
  16. Yan LP, Chan SW*, Chan ASC, Chen SL, Ma XJ, Xu HX. (2006) Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sciences. 79:324-330.
  17. Tam HL, Chan SW, Guo DJ, Yu PHF. (2006) The pharmacological role of Radix Astragali (Huang Qi) in the treatment of diabetes. Hong Kong Food Science and Technology Association 9th Anniversary Commemorative Publication. 55-58.
  18. Seto SW, Lam TY, Leung GPH, Au ALS, Ngai SM, Chan SW, Kwan YW. (2007) Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activator receptor-g activation in +db/+m and +db/+db mice. European Journal of Pharmacology. 572:40-48.
  19. Hao XN, Chan SW*, Chen SL. (2007) Detection of puerarin and danshensu in traditional Chinese medicinal preparation containing Pueraria lobata and Salvia miltiorrhiza by high-performance liquid chromatography. Journal of Liquid Chromatography and Related Technologies. 30:2779-2787.
  20. Chan SW, Rudd JA, Lin G, Li P. (2007) Action of anti-tussive drugs on the emetic reflex of Suncus murinus (House Musk Shrew). European Journal of Pharmacology. 559:196-201.
  21. Li WY, Chan SW*, Yu PHF, Guo DJ. (2007) Correlation between antioxidative power and anticancer activity in herbs from traditional Chinese medicine formulae with anticancer therapeutic effect. Pharmaceutical Biology. 45:541-546.
  22. Seto SW, Au ALS, Lam TY, Chim SSC, Lee SMY, Wan S, Tjiu DCS, Shigemura N, Yim APC, Chan SW, Tsui SKW, Leung GPH, Kwan YW. (2007) Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. British Journal of Pharmacology. 151:987-997.
  23. Leung TY, Chan SW, Yu PHF, Guo DJ, Cheng HL, Wu JH. (2007) A scientific review on the anticancer effects of Scutellaria Barbata (Ban Zhi Lian). Hong Kong Food Science and Technology Association 10th Anniversary Commemorative Publication. 64-69.
  24. 郭德建, 汪程远, 仲小青, 陳舜宏, 范立梅, 余海虎 (2007) 常用五种植物香料抗氧化活性研究. 食品科学, 28: 454-457.
  25. Chan YS, Cheng LN, Yu PHF, Seto SW, Kwan YW, Wu JH, Guo DJ, Cheng HL, Chan SW*. (2007) A scientific review on the therapeutic uses of Arctium Lappa extract. Hong Kong Food Science and Technology Association 10th Anniversary Commemorative Publication. 59-62.
  26. 张萌, 曹新伟, 吴健虹, 陈士林, 陈舜宏* (2008) 粉防已碱的抗氧化能力与心肌保护作用的相关性研究. 世界科学技术-中医药现代化. 10: 21-26. 
  27. Guo DJ, Cheng HL, Wu JH, Wan CW, Chan SW, Yu PHF. (2008) Antioxidants in food provide protection against neurodegenerative disease. Hong Kong Food Science and Technology Association 11th Anniversary Commemorative Publication. 39-40.
  28. Guo DJ, Cheng HL, Chan SW, Yu PHF. (2008) Antioxidant activity and the total phenolic content of tonic Chinese Medicinal Herbs. Inflammopharmacology. 16: 1-7.
  29. So CH, Chan E, Guo DJ, Cheng HL, Wu JH, Li Q, Zhang M, Chen SL, Yu PHF, Chan SW*. (2008) scientific review on the therapeutic effects of Rhodiola rosea on heart diseases and cancers. Hong Kong Food Science and Technology Association 11th Anniversary Commemorative Publication.41-43.
  30. Chan SW, Li S, Kwok CY, Benzie IFF, Szeto YT, Guo DJ. He XP, Yu PHF. (2008) Studies on the Antioxidant Activity of Chinese Medicinal Herbs. Pharmaceutical Biology. 48:587-595.
  31. Chen C, Cheng YC, Yu CH, Chan SW, Cheung MK, Yu PHF. (2008) In vitro cytotoxicity, hemolysis assay, and biodegradation behavior of biodegradable poly(3-hydroxybutyrate)-poly(ethylene glycol)-poly(3-hydroxybutyrate) nanoparticles as potential drug carriers. Journal of Biomedical Materials Research. Part A. 87:290-298.
  32. Meng Z, Chen SL, Seto SW, Kwan YW, Chan SW*. (2009) Correlation of Anti-oxidative property and Vaso-relaxation Effect of Major Active Constituents of Traditional Chinese Medicine. Pharmaceutical Biology. 47:366-371.
  33. Seto SW, Lam TY, Tam HL, Au ALS, Chan SW, Wu JH, Yu PHF, Leung GPH, Ngai SM, Yeung JHK, Leung PS, Lee SMY, Kwan YW. (2009) Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice. Phytomedicine. 16:426-436.
  34. Seto SW, Lau WS, Lam HY, Au ALS, Chim SSC, Ngai SM, Chan SW, Leung DTN, Kwan YW. (2009) Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery. European Journal of Pharmacology. 605:129-137.
  35. Yan LP, Zhuang YL, Chan SW, Chen SL, Shi GG. (2009) Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. Naunyn Schmiedebergs Arch Pharmacology. 379:587-597.
  36. Li RWS, Seto SW, Au ALS, Kwan YW, Chan SW, Lee SMY, Tse CM, Leung GPH. (2009) Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells. European Journal of Pharmacology. 612:15-20.
  37. Li WY, Chan SW*, Guo DJ, Chung MK, Leung TY, Yu PHF. (2009) Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines. Journal of Ethnopharmacology. 124:251-256.
  38. Li Q, Wu JH, Guo DJ, Cheng HL, Chen SL, Chan SW*. (2009) Suppression of diet-induced hypercholesterolemic atherosclerosis by scutellarin in rats. Planta Medica. 75:1203-1208.
  39. Lam TY, Seto SW, Au ALS, Poon CCW, Lam HY, Lau MW, Chan SW, Ngai SM, Leung GPH, Lee, SMY, Tsui SKY, Kwan YW. (2009) Folic Acid Supplementation Modifies b-Adrenoceptor-Mediated in vitro Lipolysis of Obese/Diabetic (+db/+db) Mice. Experimental Biology and Medicine. 16:426-436.
  40. Chan E, Yu PHF, Chan SW*. (2009) A potential antioxidant nutraceutical, Radix Scutellariae baicalensis. Hong Kong Food Science and Technology Association 12th Anniversary Commemorative Publication. 25-28.
  41. Wan CW, Lee YK, Kwok CY, Chan RYK, Yu PHF, Chan SW*. (2010) A validated HPLC method with dual wavelength detection on chlorogenic acid and internal standard in plasma and its application in pharmacokinetic study in rats. Journal of Liquid Chromatography & Related Technologies. 33:324-335.
  42. Alex D, Leong EC, Zhang ZJ, Yan GTH, Cheng SH, Leong CW, Li ZH, Lam KH, Chan SW, Lee SMY. (2010) Resveratrol derivative, trans-3,5,4’-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2/KDR and cell-cycle modulation. Journal of Cellular Biochemistry. 109:339-346.
  43. Wu JH, Li Q, Wu MY, Guo DJ, Chen HL, Chen SL, Seto SW, Au ALS, Poon CCW, Leung GPH, Lee SMY, Kwan YW, Chan SW* (2010) Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways. Journal of Nutritional Biochemistry. 21(7):613-620.
  44. Seto SW, Lam TY, Or PMY, Lee WYW, Au ALS, Poon CCW, Chan SW, Yeung JHK, Leung GPH, Lee SMY, Ngai SM, Kwan YW. (2010) Folic acid consumption reduces resistin level and restores the blunted acetylcholine-induced aortic relaxation in obese/diabetic mice. Journal of Nutritional Biochemistry. 21(9):872-880.
  45. Chan E, Wong CYK, Wan CW, Kwok CY, Wu JH, Ng KM, So CH, Au ALS, Poon CCW, Seto SW, Kwan YW, Yu PHF, Chan SW*. (2010) Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer. American Journal of Chinese Medicine. 38(4):815-827.
  46. Kwok CY, Wong CNY, Yau, MYC, Yu PHF, Au ALS, Poon CCW, Seto SW, Lam TY, Kwan YW, Chan SW*. (2010) Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high cholesterol diet-induced hypercholesterolemia in rats. Journal of Functional Foods. 2(3):179-186.
  47. Yang C, Kwan YW, Au AL, Poon CC, Zhang Q, Chan SW, Lee SM, Leung GP. (2010) 14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. Prostaglandins and Other Lipid Mediators. 93(1-2):44-51.
  48. Tang JY, Li S, Li ZH, Zhang ZJ, Hu G, Cheang LC, Alex D, Hoi MP, Kwan YW, Chan SW, Leung GP, Lee SM. (2010) Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC. PLoS One. 5(7):e11822.
  49. Yang C, Kwan YW, Chan SW, Lee SM, Leung GP. (2010) Potentiation of EDHF-mediated relaxation by chloride channel blockers. Acta Pharmacologica Sinica. 31(10):1303-1311.
  50. Poon CC, Seto SW, Au AL, Zhang Q, Li RW, Lee WY, Leung GP, Kong SK, Yeung JH, Ngai SM, Ho HP, Lee SM, Chan SW, Kwan YW. (2010) Mitochondrial monoamine oxidase-A-mediated hydrogen peroxide generation enhances 5-hydroxytryptamine-induced contraction of rat basilar artery. British Journal of Pharmacology. 161(5):1086-1098.
  51. Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW*. (2011) A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 19(5):245-254.
  52. Chan JY, Chan E, Chan SW*, Sze SY, Chan MF, Tsui SH, Leung KY, Chan RY, Chung IY. (2011) Enhancement of in vitro and in vivo anticancer activities of polysaccharide peptide from Grifola frondosa by chemical modifications. Pharmaceutical Biology. 49(11): 1114-1120.
  53. Li S, Lou S, Lei BUW,  Chan TF, Kwan YW, Chan SW, Leung GPH, Tsui SKW, Lee SMY. (2011) Transcriptional Profiling of Angiogenesis Activities of Calycosin in Zebrafish. Molecular BioSystems. 7(11):3112-3121.
  54. Yiu WF, Kwan PL, Wong CY, Kam TS, Chiu SM, Chan SW, Chan R. (2011) Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase. Journal of Food Sciences. 76(3):H80-H89.
  55. Chan E, Liu XX, Guo DJ, Kwan YW, Leung GP, Lee SM, Chan SW*. (2011) Extract of Scutellaria baicalensis Georgi Root Exerts Protection Against Myocardial Ischemia-Reperfusion Injury in Rats. American Journal of Chinese Medicine. 39(4):693-704.
  56. Wang N, Wan JB, Chan SW, Deng YH, Yu N, Zhang QW, Wang YT, Lee SM. (2011) Comparative study on saponin fractions from Panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion. Chinese Medicine. 13;6:37.
  57. Chan SW, Li P, Kwan YW, Lin G. (2011) In vitro Tracheobronchial Relaxation of Fritillaria Alkaloids. Chinese Journal of Natural Medicines. 9(5):345-353.
  58. Wu JH, Wang QH, Li F, Shu YL, Chan CO, Mok DKW, Chan SW*. (2012) Suppression of Diet-Induced Hypercholesterolemia by Turtle Jelly, a Traditional Chinese Functional Food, in Rats. Evidence-Based Complementary and Alternative Medicine. 2012:320304
  59. Zhou X, Chan SW, Tseng HL, Deng Y, Hoi PM, Choi PS, Or PM, Yang JM, Lam FF, Lee SM, Leung GP, Kong SK, Ho HP, Kwan YW, Yeung JH. (2012) Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions. Phytomedicine. 19(14):1263-1269.
  60. Chan E, Chan JYY, Wu JH, Wan CW, Leung GPH, Lee SMY, Kwan YW, Chan SW*. (2012) Serum nitric oxide synthase activity is a novel predictor of impaired vasorelaxation in rats. Clinical and Experimental Pharmacology and Physiology. 39(10): 894-896.
  61. Chan SW*. (2012) Panax ginseng, Rhodiola rosea and Schisandra chinensis. International Journal of Food Sciences and Nutrition. 63 S1:75-81.
  62. Kam TS, Wong CY, Kwan PL, Fat-Yiu W, Chiu SM, Chan SW, Yuen KS, Chan R. (2012) Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats. Journal of Medicinal Food. 15(2):190-199.
  63. Zhang Y,  Hu G, Li S, Li ZH, Lam CO, Hong SJ, Kwan YW, Chan SW, Leung GP, Lee SM (2012) Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo. Molecular Medicine Reports. 5(3):805-811.
  64. Hu G, Siu SO, Li S, Chu IK, Kwan YW, Chan SW, Leung GP, Yan R, Lee SM (2012). Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae. Xenobiotica. 42(3):294-303.
  65. Li CM, Yang RF, Gu QL, Wang B, Wu JH, Fan XD, Chan SW, Qiu TQ, Wong MS. (2012) Effects of aqueous extract from Salvia miltiorrhiza Bunge on serum lipid level and liver in ovariectomized rats. Huanan Ligong Daxue Xuebao/Journal of South China University of Technology (Natural Science). 40: 151-156.
  66. Tang WM, Chan E, Kwok CY, Lee YK, Wu JH, Wan CW, Chan RY, Yu PH, Chan SW*. (2012) A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology. 20(6):307-314.
  67. Li RW, Yang C, Kwan YW, Chan SW, Lee SM, Leung GP. (2013) Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Frontiers in Pharmacology. 4:14.
  68. Zhang H, Li C, Kwok ST, Zhang QW, Chan SW*. (2013) A review of the pharmacological effects of the dried root of Polygonum cuspidatum (Huzhang) and its constituents. Evidence-Based Complementary and Alternative Medicine. 2013: 208349.
  69. Chan GHH, Law BYK, Chu JMT, Yue KKM, Jiang ZH, Lau CW, Huang Y, Chan SW, Yue PYK, Wong RNS, (2013) Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and down-regulation of atherosclerosis-related genes. Evidence-Based Complementary and Alternative Medicine. 2013: 797310.
  70. Seto SW, Au AL, Poon CC, Zhang Q, Li RW, Yeung JH, Kong SK, Ngai SM, Wan S, Ho HP, Lee SM, Hoi MP, Chan SW*, Leung GP, Kwan YW. (2013) Acute Simvastatin Inhibits K ATP Channels of Porcine Coronary Artery Myocytes. PLoS One. 8(6):  e66404.
  71. Ng YF, Wong, SL, Cheng HL, Yu PHF, Chan SW*. (2013) The microbiological quality of ready-to-eat food in Siu Mei and Lo Mei shops in Hong Kong. Food Control. 34: 547-553.
  72. Sham TT, Yuen ACY, Ng, YF, Chan CO, Mok DKW, Chan SW*. (2013) A Review of the Phytochemistry and Pharmacological Activities of Raphani Semen. Evidence-Based Complementary and Alternative Medicine. 2013: 636194.
  73. Kwok CY, Li C, Cheng HL, Ng YF, Chan TY, Kwan YW, Leung GPH, Lee SMY, Mok DKW, Yu PHF, Chan SW*. (2013) Cholesterol Lowering and Vascular Protective Effects of Ethanolic Extract of Dried Fruit of Crataegus pinnatifida, hawthorn (Shan Zha), in Diet-induced Hypercholesterolaemic Rat Model. Journal of Functional Foods. 5: 1326-1335.
  74. Li CM, Wu JH, Yang RF, Dong XL, He ZY, Tian XL, Guo DJ, Wong MS, Qiu TQ, Chan SW*. (2013) Ligusticum chuanxiong Prevents Ovariectomy-Induced Liver and Vascular Damages in Rats.  American Journal of Chinese Medicine. 41(4): 831-848.
  75. Wu JH, Leung GPH, Kwan YW, Sham TT, Tang JY, Wang YH, Wan JB, Lee SMY, Chan SW*. (2013) Suppression of Diet-Induced Hypercholesterolaemia by Saponins from Panax notoginseng in Rats. Journal of Functional Foods. 5: 1159-1169.
  76. Li WY, Chan RYK, Yu PHF, Chan SW*. (2013) Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes. Pharmaceutical Biology. 51(9): 1175-1181.
  77. Li F, Wu JH, Wang QH, Shu YL, Wan CW, Chan CO, Mok DKW, Chan SW*. (2013) Gui-ling-gao, a traditional Chinese functional food, prevents oxidative stress-induced apoptosis in H9c2 cardiomyocytes. Food & Function. 4: 745-753.
  78. Chan JYY, Yuen ACY, Chan RYK, Chan SW*. (2013) A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin. Phytotherapy Research. 27: 637-646.
  79. Zhang H, Wu MY, Guo DJ, Wan CW, Lau CC, Chan CO, Mok DKW, Chan SW*. (2013) Gui-ling-gao (turtle jelly), a traditional Chinese functional food, exerts anti-inflammatory effects by inhibiting iNOS and pro-inflammatory cytokine expressions in splenocytes isolated from BALB/c mice. Journal of Functional Foods. 5: 625-632
  80. Wan CW, Wong CNY, Pin WK, Wong MHY, Kwok CY, Chan RYK, Yu PHF, Chan SW*. (2013) Chlorogenic Acid Exhibits Cholesterol Lowering and Fatty Liver Attenuating Properties by Upregulating the Gene Expression of PPAR-a in Hypercholesterolemic Rats Induced with a High-Cholesterol Diet. Phytotherapy Research. 27: 545-551.
  81. Li CM, Dong XL, Fan XD, Wu JH, Wang QH, Tian XL, Guo DJ, Wong MS, Qiu TQ, Chan SW* (2013) Aqueous Extract of Danshen (Salvia Miltiorrhiza Bunge) Protects Ovariectomized Rats Fed with High-fat Diet from Endothelial Dysfunction. Menopause. 20(1):100-109.
  82. Guo DJ, Li F, Yu PHF, Chan SW*. (2013) Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxy dopamine on rat pheochromocytoma PC12 cells. Pharmaceutical Biology.   51(2): 190-196.
  83. Chan SH, Chui CH, Chan SW, Kok SHL, Chan D, Tsoi MYT, Leung PHM, Lam AFY, Chan ASC, Lam KH, Tang JCO. (2013) Synthesis of 8-Hydroxyquinoline Derivatives as Novel Antitumor Agents. ACS Medicinal Chemistry Letter. 4: 170-174.
  84. Wu J, Liu X, Chan CO, Mok DK, Chan SW*, Yu Z, Chen S. (2014) Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats. Journal of Ethnopharmacology. 157: 45-54.
  85. Li S, Dang YY, Che GOL, Kwan YW, Chan SW, Leung GPH, Lee SMY, Hoi MPM. (2014) VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicology and Applied Pharmacology. 280(3): 408-420.
  86. Tang PC, Ng YF, Ho S, Gydad M, Chan SW*. (2014) Resveratrol and Cardiovascular Health - Promising Therapeutic or Hopeless Illusion? Pharmacological Research. 90: 88-115.
  87. Li CM, Guo YQ, Dong XL, Li H, Wang B, Wu JH, Wong MS, Chan SW*. (2014) Ethanolic extract of Rhizome of Ligusticum Chuanxiong Hort. (Chuanxiong) enhances endothelium-dependent vascular reactivity in ovariectomized rats fed with high-fat diet. Food & Function. 5(10): 2475-2485.
  88. Tang YL, Chan SW*. (2014) A Review of the Pharmacological Effects of Piceatannol on Cardiovascular Diseases. Phytotherapy Research. 28(11): 1581-1588.
  89. Chan JYY, Tsui HT, Chung IYM, Chan RYK, Kwan YW, Chan SW*. (2014) Allicin protects rat cardiomyoblasts (H9c2 cells) from hydrogen peroxide-induced oxidative injury through inhibiting the generation of intracellular reactive oxygen species. International Journal of Food Sciences and Nutrition. 65(7): 868-873.
  90. Li RWS, Yang C, Sit ASM, Kwan YW, Lee SMY, Hoi MPM, Chan SW, Hausman M, Vanhoutte PM, Leung GPH. (2014) Uptake and protective effects of ergothioneine in human endothelial cells. The Journal of Pharmacology and Experimental Therapeutics. 350(3): 691-700.
  91. Ng YF, Tang PC, Sham TT, Lam WS, Mok DK, Chan SW*. (2014) Semen Astragali Complanati: An ethnopharmacological, phytochemical and pharmacological review. Journal of Ethnopharmacology. 155(1): 39-53.
  92. Sham TT, Chan CO, Wang YH, Yang JM, Mok DKW, Chan SW*. (2014) A review on the traditional Chinese medicinal herbs and formulae with hyperlipidaemic effect. BioMed Research International. 2014:925302.
  93. Szeto W, Kan CW, Yuen CWM, Chan SW*, Lam KH. (2014) Effective Photodegradation of Methyl Orange Using Fluidized Bed Reactor Loaded with Cross-Linked Chitosan Embedded Nano-CdS Photocatalyst. International Journal of Chemical Engineering. 2014:270946.
  94. Li WY, Ng YF, Zhang H, Guo ZD, Guo DJ, Kwan YW, Leung GPH, Lee SMY, Yu PH, Chan SW*. (2014) Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. Inflammopharmacology. 22(2):127-134.
  95. Chan CO, Lau CC, Ng YF, Xu LJ, Chen SB, Chan SW, Mok DKW. (2015) Discrimination between leave of Apocynum venetum and its adulterant, A. pictum based on antioxidant assay and chemical profiles combined with multivariate statistical analysis. Antioxidants. 4(2):359-372.
  96. Zhang LQ, Sa F, Chong CM, Wang Y, Zhou ZY, Chang CC, Chan SW, Hoi PM, Yuen Lee SM. (2015) Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. Journal of Ethnopharmacology. 170: 5-15
  97. Li RW, Yang C, Shan L, Zhang Z, Wang Y, Kwan YW, Lee SM, Hoi MP, Chan SW, Cheung AC, Cheung KH, Leung GP. (2015) Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. European Journal of Pharmacology. 761: 153-160.
  98. Li RW, Yang C, Chan SW, Hoi MP, Lee SM, Kwan YW, Leung GP. (2015) Relaxation effect of abacavir on rat basilar arteries. PLoS One. 10(4): e0123043.
  99. Li S, Zhou XL, Dang YY, Kwan YW, Chan SW, Leung GPH, Lee SMY, Hoi MPM. (2015) Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochimica et Biophysica Acta - General Subjects. 1850(2): 373-384.
  100. Li JJ, Zhou SY, Lam KH, Yu PHF, Lee SMY, Chan SW*. (2015) Cortex Fraxini (Qingpi) Protects Rat Pheochromocytoma (PC12) Cells Against 6-hydroxydopamine-induced Apoptosis. Parkinson's Disease. 2015: 532849.
  101. Yang RF, Zhao C, Chen X, Chan SW*, Wu JY. (2015) Chemical properties and bioactivities of Goji (Lycium barbarum) polysaccharides extracted by different methods. Journal of Functional Foods. 17: 903–909.
  102. Zhang SY, Chan SW, Zhou X, Chen XL, Mok DKW, Lin ZX, Wang YH. (2015) Meta-analysis of association between ALDH2 rs671 polymorphism and essential hypertension in Asian populations. Herz. 40(S2):203-208.
  103. Guo YQ, Sun HY, Chan CO, Liu BB, Wu JH, Chan SW, Mok DK, Tse AK, Yu ZL, Chen SB. (2015) Centipeda minima (Ebushicao) extract inhibits PI3K-Akt-mTOR signaling in nasopharyngeal carcinoma CNE-1 cells. Chinese Medicine. 10: 26.
  104. Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM. (2015) A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo. Molecular Pharmaceutics. 12(10):3507-3517.
  105. Cui GZ, Shan LC, Chu IK, Li GH, Leung GPH, Wang YQ, Hoi PM, Kwan YW, Chan SW, Lee SMY. (2015) Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agent. RSC Advances. 5:74605-74610.
  106. Poon CC, Li RW, Seto SW, Kong SK, Ho HP, Hoi MP, Lee SM, Ngai SM, Chan SW, Leung GP, Kwan YW. (2015) In vitro vitamin K2 and 1α,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice. European Journal of Pharmacology. 767:30-40.
  107. Li S, Dang Y, Zhou X, Huang B, Huang X, Zhang Z, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP. (2015) Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Scientific Report. 5:16815.
  108. Sun HY, Liu BB, Hu JY, Xu LJ, Chan SW, Chan CO, Mok DK, Zhang DM, Ye WC, Chen SB. (2016) Novel cycloartane triterpenoid from Cimicifuga foetida (Sheng ma) induces mitochondrial apoptosis via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation in human breast carcinoma MCF-7 cells. Chinese Medicine. 11: 1.
  109. Gao X, Li C, Tang YL, Zhang H, Chan SW*. (2016) Effect of Hedyotis diffusa water extract on protecting human hepatocyte cells (LO2) from H2O2-induced cytotoxicity. Pharmaceutical Biology. 54(7): 1148-1155.
  110. Liang WL, Pan YL, Cheng HL, Li TC, Yu PHF, Chan SW*. (2016) The microbiological quality of take-away raw salmon finger sushi sold in Hong Kong. Food Control. 69: 45-50.
  111. Zhou X, Cui G, Tseng HHL, Lee SMY, Leung GP, Chan SW, Kwan YW, Hoi MP. (2016) Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine.  Evidence-Based Complementary and Alternative Medicine. 2016: 9627258.
  112. Zhou X, Choi PS, Yang JM, Or PMY, Hoi PM, Lee SMY, Leung GPH, Ngai SM, Kong SK, Ho HP, Wong MYM, Chan SW*, Yeung JHK, Kwan YW. (2016) Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods. SpringerPlus. 5: 1438.
  113. Sham TT, Zhang H, Mok DKW, Chan SW*, Wu JH, Tang SG, Chan CO. (2017) Hypercholesterolemia study of Astragali Complanati Semen by using serum metabolomics based on gas chromatography – mass spectrometry. Antioxidants. 2017, 6(3):57.
  114. Li S, Ai N, Shen M, Dang Y, Chong CM, Pan P, Kwan YW, Chan SW, Leung GPH, Hoi MPM, Hou T, Lee SM. (2017) Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin. Cell Death Discovery. 3: 17051.
  115. Chan JY, Zhou H, Kwan YW, Chan SW, Radis-Baptista G, Lee SM. (2017) Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics. Journal of Biochemical and Molecular Toxicology. 31(11): e21964.
  116. Gao L, Siu PM, Chan SW, Lai WKC. (2017) Cardiovascular protective effects of Salvianic Acid A in db/db mice with elevated homocysteine level. Oxidative Medicine and Cellular Longevity. 2017: 9506925.
  117. Zhang H, Zhou XL, Wong MHY, Man KY, Pin WK, Yeung JHK, Kwan YW, Leung GPH, Hoi PM, Lee SMY, Chan CO, Mok DKW, Yu PHF, Chan SW*. (2017) Sichuan pepper attenuates H2O2-induced apoptosis via antioxidant activity and up-regulating heme oxygenase-1 gene expression in primary rat hepatocytes. Journal of Food Biochemistry. 41: e12403.
  118. Zhang H, Wu MY, Guo DJ, Wan CW, Chan SW*. (2017) Gui-ling-gao inhibits concanavalin A-induced inflammation by suppressing the expressions of iNOS and pro-inflammatory cytokines in mice isolated splenocytes. Journal of Food Biochemistry. 41: e12367.
  119. Lam W, Wang Y, Chan PL, Chan SW, Tsang YF, Chua H, Yu PHF. (2017) Production of polyhydroxyalkanoates (PHA) using sludge from different wastewater treatment processes and the potential for medical and pharmaceutical applications. Environmental Technology. 38(13-14): 1779-1791.
  120. Sham TT, Li MH, Chan CO, Zhang H, Chan SW, Mok DKW. (2017) Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics. Journal of Functional Foods. 28: 127-137.
  121. Wu X, Chan SW, Ma J, Li P, Shaw PC, Lin G. (2018) Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species. Journal of Ethnopharmacology. 210: 39-46.
  122. Wang L, Jiang W, Shen X, Li X, Huang XA, Xu Z, Sun Y, Chan SW, Zeng L, Eremin SA, Lei H. (2018) Four Hapten Spacer Sites Modulating Class Specificity: Nondirectional Multianalyte Immunoassay for 31 β-Agonists and Analogues. Analytical Chemistry. 90(4): 2716-2724.
  123. Xu S, Zhang H, Pao PC, Lee A, Wang J, Chan YS, Manno FA, Chan SW, Cheng SH, Chen X. (2020) Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons. Aquatic Toxicology. 222: 105469.
  124. Au DCT, Law SK, Chow WYL, Poon CH, Chow KKC, Zhao ZZ, Chan SW, Wang YP, Li SM. (2023) Behavioral Prevention, Treatment, and Rehabilitation of using Western and Chinese medicines or Herbal products among the public in response to COVID-19 in Hong Kong: A cross-sectional study. Evidence-Based Complementary and Alternative Medicine. 2023, 5637720.
  125. Kwong TC, Chau ECT, Mak MCH, Choy CT, Chan LT, Pang CK, Zhou J, Poon PHC, Guan Y, Tsui SKW, Chan SW, Leung GP, Tai WCS, Kwan YW, (2023) Characterization of the Gut Microbiome in Healthy Dogs and Dogs with Diabetes Mellitus. Animals. 2023, 13, 2479.
  126. Chau ECT, Kwong TC, Pang CK, Chan LT, Chan AML, Yao X, Tam JSL, Chan SW, Leung GPH, Tai WCS, Kwan YW, (2023) A Novel Probiotic-Based Oral Vaccine against SARS-CoV-2 Omicron Variant B.1.1.529. International Journal of Molecular Sciences. 2023, 24, 13931.