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讲师

食品及健康科学学系

联络方法

电邮: marvinmak@thei.edu.hk

电话: +852 3890 8518

TEACHING AREAS
  1. Nutritional Science
  2. Epidemiology
  3. Human Physiolog
  4. General Biology
  5. Molecular Biology
  6. Microbiology
  • 2019 – PhD in Neuropharmacology, The Hong Kong Polytechnic University
  • 2006 – MA in Chinese Studies, The Hong Kong University of Science and Technology
  • 2004 – BSc (Hons) in Biochemistry, The Hong Kong University of Science and Technology
2021 – Present Teaching Fellow, Faculty of Science and Technology, the Technological and Higher Education Institute of Hong Kong
2020 – 2021 Project Manager, ZhaoKe (HK) Ophthalmology Pharmaceutical
2019 – 2020 Research Associate, Division of Life Science, The Hong Kong University of Science and Technology
2014 – 2015 Research Assistant, Applied Biology & Chemical Technology, The Hong Kong Polytechnic University
2013 – 2014 Research Assistant, Division of Life Science, The Hong Kong University of Science and Technology
2013 – 2013 Research Assistant, Department of Pharmacy, The Chinese University of Hong Kong
2007 – 2013

Research Assistant, Applied Biology & Chemical Technology, The Hong Kong Polytechnic University
2006 – 2007 Research Assistant, Department of Biochemistry, The Hong Kong University of Science and Technology
  • Molecular and Cellular mechanisms of Neurodegenerative Disorders 
  •  Development of novel treatment for Alzheimer’s disease and Parkinson’s disease
    1. Liu Y, Zhang Z, Zhu Z, Yang Y, Peng W, Chen Q, Mak SH, Tism KW, Pi R. (2025) Cinnamic Acid Derivatives: Recent Discoveries and Development Strategies for Alzheimer’s Disease. Mini Rev Med Chem. 25(2):163-175.
    2. Xia Y, Wu Q, Mak SH, Liu EYL, Zheng BZY, Dong TTX, Pi R, Tsim KWK. (2022) Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells. FASEB J. 36(3):e22189.
    3. Chen C*, Lu J*, Peng W*, Mak SH*, Yang Y, Zhu Z, Wang S, Hou J, Zhou X, Xin W, Hu Y, Tsim KWK, Han Y, Liu Q, Pi RB. (2021) Acrolein, an endogenous aldehyde induces Alzheimer’s disease-like pathologies in mice: A new sporadic AD animal model. Pharmacol Res. 175:106003. *The authors contributed equally to this work.
    4. Gao X, Xia TC, Mak SH, Kwan KL, Zheng ZY, Xiao J, Dong TT, Tsim KWK. (2021) Luteolin stimulates the NGF-induced neurite outgrowth in cultured PC12 cells through binding with NGF and potentiating its receptor signalling. Food Funct. 12(22):11515-11525.
    5. Xuan Z, Gu X, Yan S, Xie Y, Zhou Y, Zhang H, Jin H, Hu S, Mak SH, Zhou D, Keung Tsim KW, Carlier PR, Han Y, Cui W. (2021) Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer’s Disease. ACS Chem Neurosci;12(13):2462-2477.
    6. Wu L, Zhou X, Cao Y, Mak SH, Zha L, Li N, Su Z, Han Y, Wang Y, Man Hoi MP, Sun Y, Zhang G, Zhang Z, Yang X. (2021) Therapeutic efficacy of novel memantine nitrate MN-08 in animal models of Alzheimer’s disease. Aging Cell. 20(6):e13371.
    7. Liu EYL, Mak SH, Kong X, Xia Y, Kwan KKL, Xu ML, Tsim KWK. (2021) Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. Mol Pharmacol.;100(5):456-469.
    8. Mak SH, Li WM, Fu HJ, Luo JL, Cui W, Hu SQ, Tsim, KWK, Pi RB, Han YF (2021) Promising dimeric AChE inhibitors for neurodegenerative disorders: from relieving symptoms to modifying diseases through multi-target. Journal of Neurochemistry. 158(6):1381-1393.
    9. Hu WH*, Mak SH*, Zheng ZY, Xia YJ, Xu ML, Duan R, Dong TT, Li SP, Zhan CS, Shang XH, Tsim KW. (2020) Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice. Front Pharmacol.11:1045. *The authors contributed equally to this work.
    10. Liu EYL, Xia YJ, Kong XP, Guo Maggie SS, Yu Anna XD, Zheng Brody ZY, Mak SH, Xu Miranda L, Tsim Karl WK. (2020) Interacting with α 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages. Acta Pharm Sin B. 10(10):1926-1942.
    11. Chen Q, Tu Y, Mak SH, Chen J, Lu J, Chen C, Yang X, Wang S, Wen S, Ma S, Li M, Han Y, Tsim KW, Pi RB. (2020) Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer’s disease in vitro and in vivo. Eur J Pharmacol. 883:173361.
    12. Hu S, Xian Y, Fan Y, Mak SH, Wang J, Tang J, Pang Y, Pi R, Tsim KW, Liu F, Lin Z, Han YF. (2020) Significant combination of Aβ aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer’s agent. Eur J Pharmacol. 876:173065.
    13. Mak SH, Liu Z, Wu L, Guo B, Luo F, Liu Z, Hu S, Wang J, Cui G, Sun Y, Wang Y, Zhang G, Han Y, Zhang Z. (2020) Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo. ACS Chem Neurosci. 11(3):314-327.
    14. Liu Z, Qiu XL, Mak SH, Guo BJ, Hu SQ, Wang JJ, Luo FC, Xu DP, Sun Y, Zhang GX, Cui GZ, Wang YQ, Zhang ZJ, Han YF. (2020) Multifunctional Memantine Nitrate Significantly Protects Against Glutamate-induced Excitotoxicity via Inhibiting Calcium Influx and Attenuating PI3K/Akt/GSKbeta pathway. Chemico-Biological Interactions 325:109020.
    15. Zhang L*, Chen C*, Mak SH*, Lu J, Wu Z, Chen Q, Han Y, Li Y, Pi R. (2019) Advance of sporadic Alzheimer’s disease animal models. Med Res Rev. 40(1):431-458. *The authors contributed equally to this work.
    16. Ke Z, Hu S, Cui W, Sun J, Zhang S, Mak SH, Wang J, Tang J, Pang Y, Han YF, Tong K. (2019) Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression. Neurochem Int. 128:143-153.
    17. Luo F, Wu L, Zhang Z, Zhu Z, Liu Z, Guo B, Li N, Ju J, Zhou Q, Li S, Yang X, Mak SH, Han YF, Sun Y, Wang Y, Zhang G, Zhang Z. (2019) A dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid hemorrhage models. Br J Pharmacol. 176(17):3318-3335..
    18. Weber A, Mak SH, Berenbaum F, Sellam J, Zheng YP, Han YF, Wen CY. (2019) Association between osteoarthritis and increased risk of dementia: A systemic review and meta-analysis. Medicine (Baltimore). 98(10):e14355.
    19. Hu SQ*, Mak SH*, Zuo X, Li H, Wang Y, Han Y. (2018) Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla. Front Pharmacol. 9:768. *These authors have contributed equally to this work
    20. Qian S, He L, Wang Q, Wong YC, Mak SH, Ho CY, Han YF, Zuo Z. (2018) Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer’s disease. Life Sci. 207:428-435.
    21. Chen HX, Xiang SY, Huang L, Lin JJ, Hu SQ, Mak SH, Wang C, Wang QW, Cui W, Han YF (2018) Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice. Metab Brain Dis. 33(4):1131-1139.
    22. Hu SQ, Hu H, Mak SH, Cui G, Lee M, Shan L, Wang Y, Lin H, Zhang Z, Han YF. (2018) A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor. Front Pharmacol. 12;9:73.
    23. Liu K, Lin HH, Pi RB, Mak SH, Han YF, Hu YJ. (2018) Research and development of anti-Alzheimer’s disease drugs: an update from the perspective of technology flows. Expert Opin Ther Pat. 28(4):341-350.
    24. Guo BJ, Hu SQ, Zheng C, Wang H, Luo FF, Li H, Cui W, Yang X, Cui GZ, Mak SH, Choi TC, Ma ED, Wang YQ, Lee SMY, Zhang ZJ, Han YF. (2017) Substantial protection against MPTP-associated Parkinson’s neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. 126:12-24.
    25. Lin JJ*, Mak SH*, Zhang JC, Wang JL, Xu DL, Hu SQ, Zhang ZJ, Wang QW W, Han YF, Cui W. (2017) Assessment of Neuronal Viability Using Fluorescein Diacetate-Propidium Iodide Double Staining in Cerebellar Granule Neuron Culture. J Vis Exp. (123). *These authors have contributed equally to this work.
    26. Xu DP, Chen HY, Mak SH, Hu SQ, Tsim KW, Hu YJ, Sun Y, Zhang G, Wang YQ, Zhang ZJ, Han YF. (2016) Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models. Neurochem Int. 99:194-205.
    27. Hu SQ, Wang L, Mak SH, Zhang Z, Xu DP, Li H, Li Y, Hu YJ, Lee SM, Wang YQ, Han YF. (2016) Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine. Neuromolecular Med. 18(4):561-572.
    28. Yu J, Zheng J, Lin J, Jin L, Yu R, Mak SH, Hu S, Sun H, Wu X, Zhang Z, Lee M, Tsim W, Su W, Zhou W, Cui W, Han YF, Wang Q. (2016) Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway. Cell Mol Neurobiol. 37(4):655-664.
    29. Huang L, Lin J, Xiang S, Zhao K, Yu J, Zheng J, Xu DP, Mak SH, Hu SQ, Nirasha S, Wang C, Chen X, Zhang J, Xu S, Wei X, Zhang Z, Zhou D, Zhou W, Cui W, Han YF, Hu Z, Wang QW. (2016) Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice. ACS Chem Neurosci. 7(8):1047-56.
    30. Yan L, Hu Q, Mak SH, Lou J, Xu SL, Bi CW, Zhu Y, Wang H, Dong TT, Tsim KW. (2015) A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons. Sci Rep. 6:30014.
    31. Zhao Y, Xu P, Hu S, Du L, Xu Z, Zhang H, Cui W, Mak SH, Xu DP, Shen J, Han YF, Liu Y, Xue M. (2015) Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation. Eur J Pharmacol.765:437-446.
    32. Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF. (2015) Dimeric bis (heptyl)-Cognitin Blocks Alzheimer’s β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils. CNS Neurosci Ther. 21(12):953-61.
    33. Xu ML, Bi CW, Cheng LK, Mak SH, Yao P, Luk WK, Lau KK, Cheng AW, Tsim KW. (2015) Reduced Expression of P2Y2 Receptor and Acetylcholinesterase at Neuromuscular Junction of P2Y1 Receptor Knock-out Mice. J Mol Neurosci. 57(3):446-51.
    34. Zhao Y, Xu P, Hu S, Du L, Xu Z, Zhang H, Cui W, Mak SH, Xu D, Shen J, Han YF, Liu Y, Xue M. (2015) Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation. Eur J Pharmacol. 765:437-446.
    35. Hu SQ, Cui W, Mak SH, Xu DP, Hu YJ, Tang J, Choi C, Lee MY, Pang Y, Han Y (2015) Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer’s Dimer. ACS Chem Neurosci.6(9):1536-45.
    36. Hu SQ, Cui W, Zhang Z, Mak SH, Xu DP, Li G, Hu YJ, Wang Y, Lee MY, Tsim KW, Han YF. (2015) Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. J Mol Neurosci.57(4):561-70.
    37. Chang L, Cui W, Yang Y, Xu SJ, Zhou WH, Fu HJ, Hu SQ, Mak SH, Hu JW, Wang Q, Ma Victor PY , Choi CL, Ma Edmond DL, Tao L, Pang YP, Michael J. Rowan, Roger Anwyl, Han YF, Wang QW. (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep. 5:10256.
    38. Hu SQ, Cui W, Mak SH, Choi CL, Hu YJ, Li G, Karl WK Tsim, Pang YP, Han YF. (2015) Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway. CNS Neurosci Ther. 21(6):520-9.
    39. Hu SQ, Wang R, Cui W, Zhang ZJ, Mak SH, Xu DP, Choi CL, Karl WK Tsim, Paul R. Carlier, Lee MY, Han YF (2014) Inhibiting β-amyloid-associated Alzheimer’s pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue. J Mol Neurosci. 55(4):1014-21.
    40. Qian S, He L, Mak SH, Han YF, Ho CY, Zuo Z. (2014) Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesteraseinhibitors. Int J Pharm. 477(1-2):442-53.
    41. Chao XJ, Chen ZW, Liu AM, He XX, Wang SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Cui W, Kong AN, Yu ZL, Han YF, Pi RB. (2014) Effect of Tacrine-3-caffeic Acid, A Novel Multifunctional Anti-Alzheimer’s Dimer, Against Oxidative-Stress-Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO-1 Pathway. CNS Neurosci Ther. 20(9):840-50.
    42. Mak SH, Luk WW, Cui W, Hu S, Tsim KW, Han YF. (2014) Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs. J Mol Neurosci. 53(3):511-6.
    43. Cui W, Zhang ZJ, Hu SQ, Mak SH, Xu DP, Choi CL, Wang YQ, Tsim WK, Lee MY, Rong JH, Han YF. (2014) Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction. CNS Neurosci Ther. 20(3):244-52.
    44. Hu SQ, Cui W, Mak SH, Tang J, Choi C, Pang Y, Han YF. (2013) Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways. Neurochem Int. 62(4):468-77.
    45. Cui W, Hu SQ, Chan HH, Luo J, Li W, Mak SH, Choi TC, Rong J, Carlier PR, Han Y (2012) Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. Chem Biol Interact. S0009-2797(12)00200-1
    46. Cui W, Zhang Z, Li W, Hu S, Mak SH, Zhang H, Han R, Yuan S, Li S, Sa F, Xu D, Lin Z, Zuo Z, Rong J, Ma ED, Choi TC, Lee SM, Han Y. (2012) Unexpected protection against MPP(+) -induced neurotoxicity via selectively and directly inhibiting neuronal NOS by anti-cancer agent SU4312. Br J Pharmacol. 168(5):1201-14.
    47. Cui W, Zhang ZJ, Li WM, Han RW, Mak SH, Zhang H, Hu SQ, Yuan S, Li S, Rong JH, Ma ED, Lee SM, Han YF. Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase. (2012) Plos One. 7(9); e46253
    48. Cui W, Choi Tony CL, Mak SH, Yu H, Hu SQ, Li WM , Zuo Z, Han YF, （2012）Bis(12)-hupyridone, a promising multi-functional anti-Alzheimer’s dimer derived from Chinese medicine. “Brain Disorders”, ISBN 979-953-307-186-1, 152~174. published by InTech, Croatia.
    49. Cui W, Cui GZ, Li WM, Zhang ZJ, Hu SQ, Mak SH, Zhang H, Paul R. Carlier, Choi CL, Simon, Lee MY, Han YF (2011) Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR. Brain Research. 1401:10-17.
    50. Zhang H, Mak SH, Cui W, Li WM, Han RW, Hu SQ, Ye MZ, Pi RB, Han YF. (2011) Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxyldopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry International. 59(7):981-8.
    51. Cui W, Li WM, Han RW, Mak SH, Zhang H, Hu SQ, Rong JH, Han (2011) PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochemistry International. 59(6):945-953.
    52. Hu S, Han R, Mak SH, Han YF. (2011) Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. J Ethnopharmacol. 26;135(1):34-42.
    53. Cui W, Li W, Zhao Y, Mak SH, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han YF. (2011) Preventing H2O2-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone. Brain Res. 1394:14-23.
    54. Fu H, Dou J, Li W, Cui W, Mak SH, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han YF. (2009) Promising multifunctional anti-Alzheimer’s dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. Eur J Pharmacol. 25;623(1-3):14-21.
    55. Li W, Mak SH, Jiang H, Wang Q, Pang Y, Chen K, Han YF. (2009) Novel anti-Alzheimer’s dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. Neurotherapeutics. 6(1):187-201.

• 2026 THEi Work-Integrated Learning Award of Excellence Academic Supervisor. WIL Day 2026

• Best Poster Prize, 16th International Symposium on Cholinergic Mechanisms and 2nd Misrahi Symposium on Neurobiology. Rehovot, Israel. December 8-12, 2019.

• Competitive Research Funding Schemes for the Local Self-Financing Degree Sector (Research Grants Council, HKSAR): Design and pharmacological characterizations of multifunctional anti-Parkinson’s drug leads via regulating neuroinflammation in vitro and in vivo (UGC/FDS25/M01/25) (2026.01-2027.12) HK$827,410 (an external competitive grant) (Principle Investigator)

• ITF Mainland-Hong Kong Joint Funding Scheme (The Innovation and Technology Fund, HKSAR): Hemodynamic Imaging System and the Breast Tumor Detection Through the Image Analyses with Artificial intelligence (MHX/053/22) (2025.02-2027.08) HK$ 3,226,900 (an external competitive grant) (Co-Investigator)

• Competitive Research Funding Schemes for the Local Self-Financing Degree Sector (Research Grants Council, HKSAR): Design and pharmacological elucidation of novel anti-PD hybrids: neuroprotective and disease-modifying effects via synergistically acting on GSK3β/MEF2D and MAO-B (UGC/FDS25/M03/22) (2023.01-2024.12) HK$754,693 (an external competitive grant) (Principle Investigator)

• “一种预防和治疗阿尔茨海默症的复合组合物及其应用”. (CN103989678 B) Chinese Patent, 2016.